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Enzyme potentiated desensitization, or EPD, is a treatment for allergies developed in the 1960s by Dr. Len McEwen in the United Kingdom. EPD uses much lower doses of antigens than conventional treatment, with the addition of an enzyme, β-glucuronidase. EPD is available in the United Kingdom, Canada for the treatment of hay fever, food allergy and intolerance and environmental allergies. EPD was under development for the treatment of autoimmune disease by a United Kingdom company called Epidyme also owned by Dr. McEwen which has been granted a United Kingdom patent. Despite encouraging results〔(EPD treatment of rheumatoid arthritis proof of concept results on Epidyme website ) use of EPD to treat autoimmune diseases.〕 in an experimental model of rheumatoid arthritis the company was placed into liquidation in April 2010.〔(Insolvency List )〕 ==United States use== EPD was available in the United States until 2001, when the Food and Drug Administration revoked approval for an investigative study which it had previously sanctioned which had allowed EPD to be imported into the USA without being licensed. The reason given for revoking approval was that complex mixtures of allergens used in EPD treatments were not allowed under FDA rules. Since then the FDA has banned importation of EPD〔(FDA Import Alert )〕 for the following reasons:-. * EPD is not licensed. * the labeling of the medicine does not contain adequate directions for use. (EPD is only supplied to doctors who have been through a one week training course, and instructions supplied with the medicine would not be adequate) A related treatment, Low Dose Allergens (LDA), has been developed in the US by Dr. Shrader, which, being a compounding rather than a drug, is not regulated by the FDA, and uses a different allergen mix for the US environment. However, LDA is considered by many in the field to just be a repackaging of EPD that allows its use to not be subject to the same FDA guidelines that caused EPD to be revoked.〔(EPD & LDA )〕〔(LDA Therapy )〕〔(Low Dose Immunotherapy )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Enzyme potentiated desensitization」の詳細全文を読む スポンサード リンク
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